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1

Understanding and Modulating Mammalian-Microbial Communication for Improved Human Health

Mani, Sridhar, Boelsterli, Urs A., Redinbo, Matthew R.

Journal:

Annual Review of Pharmacology

Year:

2014

Language:

english

File:

PDF, 1.52 MB

english, 2014

2

Differential toxicity of cocaine and its isomers, (+)-cocaine and (−)-Ψ-cocaine, is associated with stereoselective hydrolysis by hepatic carboxylesterases in cultured rat hepatocytes

Russell B. Melchert, Christian Göldlin, Ulrich Zweifel, Allison A. Welder, Urs A. Boelsterli

Journal:

Chemico-Biological Interactions

Year:

1992

Language:

english

File:

PDF, 922 KB

english, 1992

3

St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis

Ze-Ping Hu, Xiao-Xia Yang, Sui Yung Chan, An-Long Xu, Wei Duan, Yi-Zhun Zhu, Fwu-Shan Sheu, Urs Alex Boelsterli, Eli Chan, Qiang Zhang, Jian-Cheng Wang, Pui Lai Rachel Ee, Hwee Ling Koh, Min Huang, Sh

Journal:

Toxicology and Applied Pharmacology

Year:

2006

Language:

english

File:

PDF, 1.02 MB

english, 2006

4

Two-dimensional database of mouse liver proteins: Changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer 3-acetamidophenol

Michael Fountoulakis, Peter Berndt, Urs A. Boelsterli, Flavio Crameri, Michael Winter, Silvio Albertini, Laura Suter

Journal:

ELECTROPHORESIS

Year:

2000

Language:

english

File:

PDF, 1.49 MB

english, 2000

5

Modulation by S-Adenosyl-L-Methionine of Hepatic Na+, K+-ATPase, Membrane Fluidity, and Bile Flow in Rats with Ethinyl Estradiol-Induced Cholestasis

Urs A. Boelsterli, Gopa Rakhit, Tibor Balazs

Journal:

Year:

1983

Language:

english

File:

PDF, 676 KB

english, 1983

6

Oxygen free radical production mediated by cocaine and its ethanol-derived metabolite, cocaethylene, in rat hepatocytes

Urs A. Boelsterli, Armin Wolf, Christian Göldlin

Journal:

Year:

1993

Language:

english

File:

PDF, 827 KB

english, 1993

7

Cytotoxic activity of T cells and non-T cells from diclofenac-immunized mice against cultured syngeneic hepatocytes exposed to diclofenac

Anke Kretz-Rommel, Urs A. Boelsterli

Journal:

Year:

1995

Language:

english

File:

PDF, 1.18 MB

english, 1995

8

Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury

Calivarathan Latchoumycandane, Catherine W. Goh, Michie M.K. Ong, Urs A. Boelsterli

Journal:

Year:

2007

Language:

english

File:

PDF, 842 KB

english, 2007

9

Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition

Amanda LoGuidice, Urs A. Boelsterli

Journal:

Year:

2011

Language:

english

File:

PDF, 613 KB

english, 2011

10

Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin-α gene knockout mice

Franziska Boess, Martin Bopst, Roland Althaus, Stacey Polsky, Steven D. Cohen, Hans-Pietro Eugster, Urs A. Boelsterli

Journal:

Year:

1998

Language:

english

File:

PDF, 213 KB

english, 1998

11

An electron microscopic study of early developmental stages, myogenesis, oogenesis and cnidogenesis in the anthomedusa, Podocoryne carnea M. Sars

Journal:

Journal of Morphology

Year:

1977

Language:

english

File:

PDF, 2.84 MB

english, 1977

12

The Sod2 mutant mouse as a model for oxidative stress: A functional proteomics perspective

Yie Hou Lee, Qingsong Lin, Urs A. Boelsterli, Maxey C.M. Chung

Journal:

Mass Spectrometry Reviews

Year:

2010

Language:

english

File:

PDF, 571 KB

english, 2010

13

Proteomics profiling of hepatic mitochondria in heterozygous Sod2+/− mice, an animal model of discreet mitochondrial oxidative stress

Yie Hou Lee, Urs A. Boelsterli, Qingsong Lin, Maxey C. M. Chung

Journal:

Year:

2008

Language:

english

File:

PDF, 592 KB

english, 2008

14

Pharmacokinetic study of intraperitoneally administered troglitazone in mice using ultra-performance liquid chromatography/tandem mass spectrometry

Lee-Sun New, Sudipta Saha, Michie M. K. Ong, Urs Alex Boelsterli, Eric C. Y. Chan

Journal:

Rapid Communications in Mass Spectrometry

Year:

2007

Language:

english

File:

PDF, 212 KB

english, 2007

15

Relative cytotoxicity of psychotropic drugs in cultured rat hepatocytes

Urs A. Boelsterli, Patrick Bouis, Peter Donatsch

Journal:

Cell Biology and Toxicology

Year:

1987

Language:

english

File:

PDF, 1.10 MB

english, 1987

16

Early biochemical and morphological changes of the rat adrenal medulla induced by xylitol

Urs A. Boelsterli, Gerhard Zbinden

Journal:

Archives of Toxicology

Year:

1985

Language:

english

File:

PDF, 588 KB

english, 1985

17

Hypothetical mechanism of adrenal medullary hyperplasia in xylitol fed rats

Urs A. Boelsterli, Gerhard Zbinden

Journal:

Archives of Toxicology

Year:

1986

Language:

english

File:

PDF, 75 KB

english, 1986

18

Morphometric and biochemical analysis of adrenal medullary hyperplasia induced by nicotine in rats

Urs A. Boelsterli, Luis-M. Cruz-Orive, Gerhard Zbinden

Journal:

Archives of Toxicology

Year:

1984

Language:

english

File:

PDF, 429 KB

english, 1984

19

Biomechanisms of cocaine-induced hepatocyte injury mediated by the formation of reactive metabolites

Urs A. Boelsterli, Christian Göldlin

Journal:

Archives of Toxicology

Year:

1991

Language:

english

File:

PDF, 1.15 MB

english, 1991

20

Human Multidrug Resistance Associated Protein 4 Confers Resistance to Camptothecins

Quan Tian, Jing Zhang, Theresa May Chin Tan, Eli Chan, Wei Duan, Sui Yung Chan, Urs Alex Boelsterli, Paul Chi-Lui Ho, Hongyuan Yang, Jin-Song Bian, Min Huang, Yi-Zhun Zhu, Weiping Xiong, Xiaotian Li,

Journal:

Pharmaceutical Research

Year:

2005

Language:

english

File:

PDF, 896 KB

english, 2005

21

Reactive oxygen species and non-peroxidative mechanisms of cocaine-induced cytotoxicity in rat hepatocyte cultures

Christian R. Göldlin, Urs A. Boelsterli

Journal:

Year:

1991

Language:

english

File:

PDF, 724 KB

english, 1991

22

Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction

Chin-Ju J. Hsiao, Husam Younis, Urs A. Boelsterli

Journal:

Chemico-Biological Interactions

Year:

2010

Language:

english

File:

PDF, 600 KB

english, 2010

23

Healthy animals and animal models of human disease(s) in safety assessment of human pharmaceuticals, including therapeutic antibodies

Rakesh Dixit, Urs A. Boelsterli

Journal:

Drug Discovery Today

Year:

2007

Language:

english

File:

PDF, 511 KB

english, 2007

24

The heterozygous Sod2+/− mouse: modeling the mitochondrial role in drug toxicity

Urs A. Boelsterli, Chin-Ju J. Hsiao

Journal:

Drug Discovery Today

Year:

2008

Language:

english

File:

PDF, 334 KB

english, 2008

25

Mitochondrial permeability transition as a source of superoxide anion induced by the nitroaromatic drug nimesulide in vitro

Vincent K.S. Tay, Audrey S. Wang, Koon Yeow Leow, Michie M.K. Ong, Kim Ping Wong, Urs A. Boelsterli

Journal:

Free Radical Biology and Medicine

Year:

2005

Language:

english

File:

PDF, 464 KB

english, 2005

26

Nimesulide-induced hepatic mitochondrial injury in heterozygous Sod2+/− mice

Michie M.K. Ong, Audrey S. Wang, Koon Yeow Leow, Yok Moi Khoo, Urs A. Boelsterli

Journal:

Free Radical Biology and Medicine

Year:

2006

Language:

english

File:

PDF, 319 KB

english, 2006

27

JNK-independent Pathways of Acetaminophen-induced Hepatic Injury in Cyclophilin D-deficient Mice

Amanda LoGuidice, Urs A. Boelsterli

Journal:

Free Radical Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 387 KB

english, 2010

28

Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes

Calivarathan Latchoumycandane, Quee Ming Seah, Rachel C.H. Tan, Jetsumon Sattabongkot, Walter Beerheide, Urs A. Boelsterli

Journal:

Toxicology and Applied Pharmacology

Year:

2006

Language:

english

File:

PDF, 518 KB

english, 2006

29

Critical role of free cytosolic calcium, but not uncoupling, in mitochondrial permeability transition and cell death induced by diclofenac oxidative metabolites in immortalized human hepatocytes

Miao Shan Lim, Priscilla L.K. Lim, Rashi Gupta, Urs A. Boelsterli

Journal:

Toxicology and Applied Pharmacology

Year:

2006

Language:

english

File:

PDF, 662 KB

english, 2006

30

Mitochondrial abnormalities—A link to idiosyncratic drug hepatotoxicity?

Urs A. Boelsterli, Priscilla L.K. Lim

Journal:

Toxicology and Applied Pharmacology

Year:

2007

Language:

english

File:

PDF, 768 KB

english, 2007

31

Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced hepatocyte injury: Multiple protective roles of cyclosporin A

Woen Ping Siu, Pamela Boon Li Pun, Calivarathan Latchoumycandane, Urs A. Boelsterli

Journal:

Toxicology and Applied Pharmacology

Year:

2008

Language:

english

File:

PDF, 803 KB

english, 2008

32

Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2+/− mice: Two-stage oxidative injury

Yie Hou Lee, Maxey C.M. Chung, Qingsong Lin, Urs A. Boelsterli

Journal:

Toxicology and Applied Pharmacology

Year:

2008

Language:

english

File:

PDF, 1.25 MB

english, 2008

33

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

Rohini Kashimshetty, Varsha G. Desai, Vijay M. Kale, Taewon Lee, Carrie L. Moland, William S. Branham, Lee S. New, Eric C.Y. Chan, Husam Younis, Urs A. Boelsterli

Journal:

Toxicology and Applied Pharmacology

Year:

2009

Language:

english

File:

PDF, 1.08 MB

english, 2009

34

Effects of cocaine and its oxidative metabolites on mitochondrial respiration and generation of reactive oxygen species

Franziska Boess, Florence M Ndikum-Moffor, Urs A Boelsterli, Stephen M Roberts

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 332 KB

english, 2000

35

Down-regulation by troglitazone of hepatic tumor necrosis factor-α and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes∗

Stephan Sigrist, Marc Bedoucha, Urs A Boelsterli

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 603 KB

english, 2000

36

Toxicological consequences of altered peroxisome proliferator-activated receptor γ (PPARγ) expression in the liver: insights from models of obesity and type 2 diabetes

Urs A. Boelsterli, Marc Bedoucha

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 124 KB

english, 2002

37

Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity

Urs A Boelsterli

Journal:

Toxicology and Applied Pharmacology

Year:

2003

Language:

english

File:

PDF, 449 KB

english, 2003

38

Fructose and Tagatose Protect Against Oxidative Cell Injury by Iron Chelation

Fabio Valeri, Franziska Boess, Armin Wolf, Christian Göldlin, Urs A Boelsterli

Journal:

Free Radical Biology and Medicine

Year:

1997

Language:

english

File:

PDF, 439 KB

english, 1997

39

Effect of enzyme induction on Sandimmun® (cyclosporin A) biotransformation and hepatotoxicity in cultured rat hepatocytes and in vivo

Patrick Bouis, Jean-Francois Brouillard, Volker Fischer, Peter Donatsch, Urs A. Boelsterli

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.06 MB

english, 1990

40

Oltipraz-induced phase 2 enzyme response conserved in cells lacking mitochondrial DNA

Yee Liu Chua, Dawei Zhang, Urs Boelsterli, Philip K. Moore, Matthew Whiteman, Jeffrey S. Armstrong

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 340 KB

english, 2005

41

Induction of human sulfotransferase 1A3 (SULT1A3) by glucocorticoids

Hao Sheng Bian, Sherry Yan Yan Ngo, Weiqi Tan, Chang Hua Wong, Urs A. Boelsterli, Theresa May Chin Tan

Journal:

Year:

2007

Language:

english

File:

PDF, 349 KB

english, 2007

42

Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04

Priscilla L.K. Lim, Weiqi Tan, Calivarathan Latchoumycandane, Wei Chuen Mok, Yok Moi Khoo, How Sung Lee, Jetsumon Sattabongkot, Walter Beerheide, Seng Gee Lim, Theresa M.C. Tan, Urs A. Boelsterli

Journal:

Toxicology in Vitro

Year:

2007

Language:

english

File:

PDF, 406 KB

english, 2007

43

Luminol as a Probe to Assess Reactive Oxygen Species Production from Redox-Cycling Drugs in Cultured Hepatocytes

Boess, Franziska, Boelsterli, Urs A.

Journal:

Toxicology Mechanisms and Methods

Year:

2002

Language:

english

File:

PDF, 1.01 MB

english, 2002

44

Idiosyncratic Liver Toxicity of Nonsteroidal Antiinflammatory Drugs: Molecular Mechanisms and Pathology

Boelsterli, Urs A., Zimmerman, Hyman J., Kretz-Rommel, Anke

Journal:

Critical Reviews in Toxicology

Year:

1995

Language:

english

File:

PDF, 3.20 MB

english, 1995

45

Diclofenac acyl glucuronide, a major biliary metabolite, is directly involved in small intestinal injury in rats

Sven Seitz, Urs A. Boelsterli

Journal:

Gastroenterology

Year:

1998

Language:

english

File:

PDF, 117 KB

english, 1998

46

Determination of cocaine and norcocaine in plasma and cell cultures using high-performance liquid chromatography

Patrick Bouis, Guy Taccard, Urs A. Boelsterli

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1990

Language:

english

File:

PDF, 754 KB

english, 1990

47

Gamma-glutamyl transpeptidase (GGT) — an early marker for hepatocarcinogens in rats

Journal:

Trends in Pharmacological Sciences

Year:

1980

Language:

english

File:

PDF, 417 KB

english, 1980

48

Cytotoxic activity of T cells and non-T cells from diclofenac-immunized mice against cultured syngeneic hepatocytes exposed to diclofenac

Anke Kretz-Rommel, Urs A. Boelsterli

Journal:

Year:

1995

Language:

english

File:

PDF, 1.29 MB

english, 1995

49

Diabetic KKAy mice exhibit increased hepatic PPARγ1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones

Marc Bedoucha, Elke Atzpodien, Urs A. Boelsterli

Journal:

Journal of Hepatology

Year:

2001

Language:

english

File:

PDF, 1.19 MB

english, 2001

50

Chronic oral musk xylene (MX) induces cytochrome P4501 A in long evans rats

Regina Suter, Urs A. Boelsterli, Hans Altorfer, Walter Lichtensteiger, Margaret Schlumpf

Journal:

Toxicology Letters

Year:

1996

Language:

english

File:

PDF, 123 KB

english, 1996